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https://open.uns.ac.rs/handle/123456789/550
Title: | Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment | Authors: | Mooranian A. Zamani N. Momir Mikov Svetlana Goločorbin-Kon Goran Stojanović Arfuso F. Al-Salami H. |
Keywords: | diabetes mellitus;eudragit;microencapsulation;oral delivery;probucol;taurocholic acid | Issue Date: | 1-Feb-2019 | Journal: | Therapeutic delivery | Abstract: | AIM: Taurine-conjugated bile acids possess positive formulation-stabilization effects, which are desirable in diabetes treatments. The taurine-conjugated bile acid, taurocholic acid (TCA), has shown promising formulation-stabilizing effects on the delivery of the antioxidant drug, probucol (PB), but success is limited due to its poor release profile. This study aimed to design new PB-TCA formulations using new polymers, and examine antioxidant and antidiabetic effects using β-cells for PB with or without TCA. MATERIALS AND METHODS: Different formulations using alginate-insoluble esters of polymethylacrylate polymers encapsulating PB and TCA were developed, microencapsulated and examined for stability and biological activity. RESULTS: TCA addition to new PB matrices improved osmotic and mechanical properties, and this effect was dependent on polymethylacrylate composition and concentration. CONCLUSION: TCA can optimize the oral delivery of anti-diabetic compounds. | URI: | https://open.uns.ac.rs/handle/123456789/550 | DOI: | 10.4155/tde-2018-0034 |
Appears in Collections: | FTN Publikacije/Publications |
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