Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/550
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mooranian A. | en_US |
dc.contributor.author | Zamani N. | en_US |
dc.contributor.author | Momir Mikov | en_US |
dc.contributor.author | Svetlana Goločorbin-Kon | en_US |
dc.contributor.author | Goran Stojanović | en_US |
dc.contributor.author | Arfuso F. | en_US |
dc.contributor.author | Al-Salami H. | en_US |
dc.date.accessioned | 2019-09-23T10:08:50Z | - |
dc.date.available | 2019-09-23T10:08:50Z | - |
dc.date.issued | 2019-02-01 | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/550 | - |
dc.description.abstract | AIM: Taurine-conjugated bile acids possess positive formulation-stabilization effects, which are desirable in diabetes treatments. The taurine-conjugated bile acid, taurocholic acid (TCA), has shown promising formulation-stabilizing effects on the delivery of the antioxidant drug, probucol (PB), but success is limited due to its poor release profile. This study aimed to design new PB-TCA formulations using new polymers, and examine antioxidant and antidiabetic effects using β-cells for PB with or without TCA. MATERIALS AND METHODS: Different formulations using alginate-insoluble esters of polymethylacrylate polymers encapsulating PB and TCA were developed, microencapsulated and examined for stability and biological activity. RESULTS: TCA addition to new PB matrices improved osmotic and mechanical properties, and this effect was dependent on polymethylacrylate composition and concentration. CONCLUSION: TCA can optimize the oral delivery of anti-diabetic compounds. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Therapeutic delivery | en_US |
dc.subject | diabetes mellitus | en_US |
dc.subject | eudragit | en_US |
dc.subject | microencapsulation | en_US |
dc.subject | oral delivery | en_US |
dc.subject | probucol | en_US |
dc.subject | taurocholic acid | en_US |
dc.title | Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.4155/tde-2018-0034 | - |
dc.identifier.pmid | 10 | - |
dc.identifier.scopus | 2-s2.0-85061153376 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85061153376 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 106 | en_US |
dc.relation.firstpage | 99 | en_US |
dc.relation.issue | 2 | en_US |
dc.relation.volume | 10 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Fakultet tehničkih nauka, Departman za energetiku, elektroniku i telekomunikacije | - |
crisitem.author.orcid | https://orcid.org/0000-0002-9257-8074 | - |
crisitem.author.orcid | 0000-0003-2098-189X | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
Appears in Collections: | FTN Publikacije/Publications |
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