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https://open.uns.ac.rs/handle/123456789/32634
Nаziv: | Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healing | Аutоri: | Mozhgan Keshavarz Parvin Alizadeh Firoz Babu Kadumudi Gorka Orive Akhilesh K. Gaharwar Miguel Castilho Nasim Golafshan Alireza Dolatshahi-Pirouz |
Ključnе rеči: | alginate;laponite;hydrogels;mesenchymal stem cells;nanosilicate | Dаtum izdаvаnjа: | 19-апр-2023 | Izdаvаč: | American Chemical Society | Prојеkаt: | Twinning for reaching sustainable scientific and technological excellence in the field of Green Electronics (GREENELIT) | Čаsоpis: | ACS Applied Materials and Interfaces | Sažetak: | Several studies have shown that nanosilicate-reinforced scaffolds are suitable for bone regeneration. However, hydrogels are inherently too soft for load-bearing bone defects of critical sizes, and hard scaffolds typically do not provide a suitable three-dimensional (3D) microenvironment for cells to thrive, grow, and differentiate naturally. In this study, we bypass these longstanding challenges by fabricating a cell-free multi-level implant consisting of a porous and hard bone-like framework capable of providing load-bearing support and a softer native-like phase that has been reinforced with nanosilicates. The system was tested with rat bone marrow mesenchymal stem cells in vitro and as a cell-free system in a critical-sized rat bone defect. Overall, our combinatorial and multi-level implant design displayed remarkable osteoconductivity in vitro without differentiation factors, expressing significant levels of osteogenic markers compared to unmodified groups. Moreover, after 8 weeks of implantation, histological and immunohistochemical assays indicated that the cell-free scaffolds enhanced bone repair up to approximately 84% following a near-complete defect healing. Overall, our results suggest that the proposed nanosilicate bioceramic implant could herald a new age in the field of orthopedics. | URI: | https://open.uns.ac.rs/handle/123456789/32634 | ISSN: | 1944-8244 | DOI: | https://doi.org/10.1021/acsami.3c01717 | Prаvа: | Attribution-NonCommercial-NoDerivs 3.0 United States |
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