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https://open.uns.ac.rs/handle/123456789/32634
Поље DC-а | Вредност | Језик |
---|---|---|
dc.contributor.author | Mozhgan Keshavarz | en_US |
dc.contributor.author | Parvin Alizadeh | en_US |
dc.contributor.author | Firoz Babu Kadumudi | en_US |
dc.contributor.author | Gorka Orive | en_US |
dc.contributor.author | Akhilesh K. Gaharwar | en_US |
dc.contributor.author | Miguel Castilho | en_US |
dc.contributor.author | Nasim Golafshan | en_US |
dc.contributor.author | Alireza Dolatshahi-Pirouz | en_US |
dc.date.accessioned | 2023-11-22T11:14:31Z | - |
dc.date.available | 2023-11-22T11:14:31Z | - |
dc.date.issued | 2023-04-19 | - |
dc.identifier.issn | 1944-8244 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/32634 | - |
dc.description.abstract | Several studies have shown that nanosilicate-reinforced scaffolds are suitable for bone regeneration. However, hydrogels are inherently too soft for load-bearing bone defects of critical sizes, and hard scaffolds typically do not provide a suitable three-dimensional (3D) microenvironment for cells to thrive, grow, and differentiate naturally. In this study, we bypass these longstanding challenges by fabricating a cell-free multi-level implant consisting of a porous and hard bone-like framework capable of providing load-bearing support and a softer native-like phase that has been reinforced with nanosilicates. The system was tested with rat bone marrow mesenchymal stem cells in vitro and as a cell-free system in a critical-sized rat bone defect. Overall, our combinatorial and multi-level implant design displayed remarkable osteoconductivity in vitro without differentiation factors, expressing significant levels of osteogenic markers compared to unmodified groups. Moreover, after 8 weeks of implantation, histological and immunohistochemical assays indicated that the cell-free scaffolds enhanced bone repair up to approximately 84% following a near-complete defect healing. Overall, our results suggest that the proposed nanosilicate bioceramic implant could herald a new age in the field of orthopedics. | en_US |
dc.description.sponsorship | European Commission | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.relation | Twinning for reaching sustainable scientific and technological excellence in the field of Green Electronics (GREENELIT) | en_US |
dc.relation.ispartof | ACS Applied Materials and Interfaces | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | alginate | en_US |
dc.subject | laponite | en_US |
dc.subject | hydrogels | en_US |
dc.subject | mesenchymal stem cells | en_US |
dc.subject | nanosilicate | en_US |
dc.title | Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healing | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1021/acsami.3c01717 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 21495 | en_US |
dc.relation.firstpage | 21476 | en_US |
dc.relation.issue | 17 | en_US |
dc.relation.volume | 15 | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.project.grantno | 951747 | - |
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keshavarz-et-al-2023-multi-leveled-nanosilicate-implants-can-facilitate-near-perfect-bone-healing.pdf | 3.26 MB | Adobe PDF | Погледајте |
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