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https://open.uns.ac.rs/handle/123456789/32449
Title: | Polyelectrolytes Formulated with Primary Unconjugated Bile Acid Optimised Pharmacology of Bio-engineered Implant | Authors: | Armin Mooranian Corina Mihaela Ionescu Susbin Raj Wagle Božica Kovačević Daniel Walker Melissa Jones Jacqueline Chester Thomas Foster Edan Johnston Sanja Kojić Goran Stojanović Momir Mikov Hani Al-Salami |
Keywords: | poly-(4styrene)-sulphonate;poly-(allyl)-amine;primary bile acids;chenodeoxycholic acid;pharmacology;transplants;in vivo studies | Issue Date: | 16-Oct-2021 | Publisher: | MDPI | Project: | H2020 SALSETH | Journal: | Pharmaceutics | Abstract: | Several studies have shown that different biomaterials and hydrogels comprising various bile acids such as chenodeoxycholic acid (CDCA), as well as excipients such as poly-(styrene)-sulphonate (PSS) and poly-(allyl)-amine (PAA), exhibited positive biological effects on encapsulated viable pancreatic -cells. Hence, this study aimed to investigate whether incorporating CDCA with PSS and PAA will optimise the functions of encapsulated pancreatic islets post-transplantation in Type 1 diabetes (T1D). Methods. Mice were made T1D, divided into two equal groups, and transplanted with encapsulated islets in PSS-PAA (control) or with CDCA-PSS-PAA (treatment) microcapsules. The effects of transplanted microcapsules on blood glucose, inflammation and the bile acid profile were measured post-transplantation. Results and Conclusion. Compared with control, the treatment group showed better survival rate, improved glycaemic control, and lower inflammatory profile, illustrated by # interleukin 1- , interleukin-6, interleukin-12, and tumournecrosis factor-, and # levels of the bile acid, as well as lithocholic acid in the plasma, liver, large intestine and faeces. The results suggest that CDCA incorporation with PSS-PAA microcapsules exerted beneficial effects on encapsulated islets and resulted in enhanced diabetes treatment, posttransplantation, at the local and systemic levels. | URI: | https://open.uns.ac.rs/handle/123456789/32449 | ISSN: | 1999-4923 | DOI: | https://doi.org/ 10.3390/pharmaceutics13101713 | Rights: | Attribution-NonCommercial-NoDerivs 3.0 United States |
Appears in Collections: | FTN Publikacije/Publications |
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pharmaceutics-13-01713.pdf | 3.95 MB | Adobe PDF | View/Open |
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