Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/32449
DC Field | Value | Language |
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dc.contributor.author | Armin Mooranian | en_US |
dc.contributor.author | Corina Mihaela Ionescu | en_US |
dc.contributor.author | Susbin Raj Wagle | en_US |
dc.contributor.author | Božica Kovačević | en_US |
dc.contributor.author | Daniel Walker | en_US |
dc.contributor.author | Melissa Jones | en_US |
dc.contributor.author | Jacqueline Chester | en_US |
dc.contributor.author | Thomas Foster | en_US |
dc.contributor.author | Edan Johnston | en_US |
dc.contributor.author | Sanja Kojić | en_US |
dc.contributor.author | Goran Stojanović | en_US |
dc.contributor.author | Momir Mikov | en_US |
dc.contributor.author | Hani Al-Salami | en_US |
dc.date.accessioned | 2022-06-15T21:41:20Z | - |
dc.date.available | 2022-06-15T21:41:20Z | - |
dc.date.issued | 2021-10-16 | - |
dc.identifier.issn | 1999-4923 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/32449 | - |
dc.description.abstract | Several studies have shown that different biomaterials and hydrogels comprising various bile acids such as chenodeoxycholic acid (CDCA), as well as excipients such as poly-(styrene)-sulphonate (PSS) and poly-(allyl)-amine (PAA), exhibited positive biological effects on encapsulated viable pancreatic -cells. Hence, this study aimed to investigate whether incorporating CDCA with PSS and PAA will optimise the functions of encapsulated pancreatic islets post-transplantation in Type 1 diabetes (T1D). Methods. Mice were made T1D, divided into two equal groups, and transplanted with encapsulated islets in PSS-PAA (control) or with CDCA-PSS-PAA (treatment) microcapsules. The effects of transplanted microcapsules on blood glucose, inflammation and the bile acid profile were measured post-transplantation. Results and Conclusion. Compared with control, the treatment group showed better survival rate, improved glycaemic control, and lower inflammatory profile, illustrated by # interleukin 1- , interleukin-6, interleukin-12, and tumournecrosis factor-, and # levels of the bile acid, as well as lithocholic acid in the plasma, liver, large intestine and faeces. The results suggest that CDCA incorporation with PSS-PAA microcapsules exerted beneficial effects on encapsulated islets and resulted in enhanced diabetes treatment, posttransplantation, at the local and systemic levels. | en_US |
dc.description.sponsorship | European Commission | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation | H2020 SALSETH | en_US |
dc.relation.ispartof | Pharmaceutics | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | poly-(4styrene)-sulphonate | en_US |
dc.subject | poly-(allyl)-amine | en_US |
dc.subject | primary bile acids | en_US |
dc.subject | chenodeoxycholic acid | en_US |
dc.subject | pharmacology | en_US |
dc.subject | transplants | en_US |
dc.subject | in vivo studies | en_US |
dc.title | Polyelectrolytes Formulated with Primary Unconjugated Bile Acid Optimised Pharmacology of Bio-engineered Implant | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/ 10.3390/pharmaceutics13101713 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 16 | en_US |
dc.relation.firstpage | 1 | en_US |
dc.relation.issue | 1713 | en_US |
dc.relation.volume | 13 | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Fakultet tehničkih nauka, Departman za energetiku, elektroniku i telekomunikacije | - |
crisitem.author.dept | Fakultet tehničkih nauka, Departman za energetiku, elektroniku i telekomunikacije | - |
crisitem.author.orcid | 0000-0002-4092-9733 | - |
crisitem.author.orcid | 0000-0003-2098-189X | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
Appears in Collections: | FTN Publikacije/Publications |
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File | Description | Size | Format | |
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pharmaceutics-13-01713.pdf | 3.95 MB | Adobe PDF | View/Open |
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