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https://open.uns.ac.rs/handle/123456789/8727
Title: | Serum-based DNA methylation biomarkers in colorectal cancer: Potential for screening and early detection | Authors: | Summers T. Langan R. Nissan A. Brücher B. Bilchik A. Mlađan Protić Daumer M. Avital I. Stojadinović, Alexander |
Keywords: | Biomarker;Early detection;Colorectal cancer;DNA methylation;Screening;Serum | Issue Date: | 30-Aug-2013 | Journal: | Journal of Cancer | Abstract: | Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC. ©Ivyspring International Publisher. | URI: | https://open.uns.ac.rs/handle/123456789/8727 | DOI: | 10.7150/jca.5839 |
Appears in Collections: | MDF Publikacije/Publications |
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