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https://open.uns.ac.rs/handle/123456789/8154
Title: | Interleukin-6 cytokine: A multifunctional glycoprotein for cancer | Authors: | Zarogoulidis P. Yarmus L. Darwiche K. Walter R. Huang H. Li Z. Zarić, Bojan Tsakiridis K. Zarogoulidis K. |
Issue Date: | 1-Dec-2013 | Journal: | Immunome Research | Abstract: | Interleukin 6 is a multifunctional cytokine. Its increased levels have been associated with elevated cancer risk, and also these levels have been found to be a prognostic factor for several cancer types. In addition, increased levels have been found in coronary heart disease, insulin resistant patients, advance stage cancer patients, atopy/asthma and in patients with blood circulating micrometastasis. Additionally several studies with different types of cancers have been performed to identify the correlation between interleukin-6 levels, stage, treatment response and severity of symptoms. The influence of interleukin-6 is performed mainly through the janus kinase-signal transducer and activator of transcription-zinc finger protein 1-2 signaling pathway. As a result, the increased levels of interleukin-6 are responsible for enhanced neo-angiogenesis, inhibition of cancer cell apoptosis and deregulation of the control mechanisms in the microenvironment. In addition, increased levels of inteleukin-6 have been found to increase the production of collagen and a-actin which induce interstitial lung disease. In the current mini review we will present information regarding the interleukin-6 and published results in several cancer studies and finally we will comment in future treatment approaches blocking this cytokine in cancer patients. Copyright: © 2013 Zarogoulidis P, et al. | URI: | https://open.uns.ac.rs/handle/123456789/8154 | DOI: | 10.4172/1745-7580.1000062 |
Appears in Collections: | MDF Publikacije/Publications |
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