Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/8154
DC Field | Value | Language |
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dc.contributor.author | Zarogoulidis P. | en |
dc.contributor.author | Yarmus L. | en |
dc.contributor.author | Darwiche K. | en |
dc.contributor.author | Walter R. | en |
dc.contributor.author | Huang H. | en |
dc.contributor.author | Li Z. | en |
dc.contributor.author | Zarić, Bojan | en |
dc.contributor.author | Tsakiridis K. | en |
dc.contributor.author | Zarogoulidis K. | en |
dc.date.accessioned | 2019-09-30T09:06:56Z | - |
dc.date.available | 2019-09-30T09:06:56Z | - |
dc.date.issued | 2013-12-01 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/8154 | - |
dc.description.abstract | Interleukin 6 is a multifunctional cytokine. Its increased levels have been associated with elevated cancer risk, and also these levels have been found to be a prognostic factor for several cancer types. In addition, increased levels have been found in coronary heart disease, insulin resistant patients, advance stage cancer patients, atopy/asthma and in patients with blood circulating micrometastasis. Additionally several studies with different types of cancers have been performed to identify the correlation between interleukin-6 levels, stage, treatment response and severity of symptoms. The influence of interleukin-6 is performed mainly through the janus kinase-signal transducer and activator of transcription-zinc finger protein 1-2 signaling pathway. As a result, the increased levels of interleukin-6 are responsible for enhanced neo-angiogenesis, inhibition of cancer cell apoptosis and deregulation of the control mechanisms in the microenvironment. In addition, increased levels of inteleukin-6 have been found to increase the production of collagen and a-actin which induce interstitial lung disease. In the current mini review we will present information regarding the interleukin-6 and published results in several cancer studies and finally we will comment in future treatment approaches blocking this cytokine in cancer patients. Copyright: © 2013 Zarogoulidis P, et al. | en |
dc.relation.ispartof | Immunome Research | en |
dc.title | Interleukin-6 cytokine: A multifunctional glycoprotein for cancer | en |
dc.type | Other | en |
dc.identifier.doi | 10.4172/1745-7580.1000062 | en |
dc.identifier.scopus | 2-s2.0-84896753600 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84896753600 | en |
dc.relation.issue | 1 | en |
dc.relation.volume | 9 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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