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https://open.uns.ac.rs/handle/123456789/6759
Title: | Anti-inflammatory activity of grains of paradise (Aframomum Melegueta Schum) extract | Authors: | Ilić, Nebojša Dey M. Poulev A. Logendra S. Kuhn P. Raskin I. |
Issue Date: | 29-Oct-2014 | Journal: | Journal of Agricultural and Food Chemistry | Abstract: | © 2014 American Chemical Society. The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes. | URI: | https://open.uns.ac.rs/handle/123456789/6759 | ISSN: | 00218561 | DOI: | 10.1021/jf5026086 |
Appears in Collections: | FINS Publikacije/Publications |
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