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https://open.uns.ac.rs/handle/123456789/6670
Nаziv: | Urinary kidney injury molecule-1 rapid test predicts acute kidney injury in extremely low-birth-weight neonates | Аutоri: | Vesna Stojanović Nenad Barišić Nada Vučković Aleksandra Doronjski Amira Peco Antić |
Ključnе rеči: | biomarkers;acute kidney injury;outcome prediction;extremely low-birth-weight neonates;uKIM-1 rapid test | Dаtum izdаvаnjа: | 1-јан-2015 | Čаsоpis: | Pediatric Research | Sažetak: | © 2015 International Pediatric Research Foundation, Inc. Background:The new urinary and serum biomarkers are discovered and are being investigated. With them we can diagnose acute kidney injury (AKI) faster and more precisely and they also have a significant role in the outcome prediction.Methods:The study included 22 extremely low-birth-weight neonates who were hospitalized in the neonatal intensive care units. They were divided into two groups based on serum creatinine (SCr) level - with and without AKI. Detection and quantification of urinary kidney injury molecule-1 (uKIM-1) was done on the third day of life, using commercially available KIM-1 rapid test. Subsequently, measurements were repeated only in subjects who were diagnosed with AKI, at different values of SCr.Results:Logistic regression analysis showed that AKI is an independent risk factor for mortality. In a group of neonates with AKI, 50% of neonates administered the KIM-1 rapid test showed positive findings. KIM-1 rapid test was positive in patients with a wide range of SCr levels (range of 78.73-385 μmol/l), but all subjects had oliguria and died in the next 24 h.Conclusion:KIM-1 is a significant predictor of death. On the other hand, our study failed to prove that KIM-1 rapid test has any significance for early prediction of AKI. | URI: | https://open.uns.ac.rs/handle/123456789/6670 | ISSN: | 313998 | DOI: | 10.1038/pr.2015.125 |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
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