Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria

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Назив:	Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria
Аутори:	Ostojić, Sergej
Кључне речи:	Creatine kinase;Guanidinoacetic acid;Creatine;Mitochondria;Bioenergetics
Датум издавања:	2015
Часопис:	Journal of Bioenergetics and Biomembranes
Сажетак:	Guanidinoacetic acid (GAA) is a natural precursor of creatine, and a possible substrate for the creatine kinase (CK) enzyme system, serving as a creatine mimetic. Its direct role in cellular bioenergetics has been confirmed in several studies, however GAA utilization by CK seems to be a second-rate as compared to creatine, and compartment-dependent. Here we discuss various factors that might affect GAA use in high-energy phosphoryl transfer in the cytosol and mitochondria.
URI:	https://open.uns.ac.rs/handle/123456789/5962
ISSN:	0145-479X
DOI:	10.1007/s10863-015-9619-7
Налази се у колекцијама:	FSFV Publikacije/Publications