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https://open.uns.ac.rs/handle/123456789/5962
Title: | Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria | Authors: | Ostojić, Sergej | Keywords: | Creatine kinase;Guanidinoacetic acid;Creatine;Mitochondria;Bioenergetics | Issue Date: | 2015 | Journal: | Journal of Bioenergetics and Biomembranes | Abstract: | Guanidinoacetic acid (GAA) is a natural precursor of creatine, and a possible substrate for the creatine kinase (CK) enzyme system, serving as a creatine mimetic. Its direct role in cellular bioenergetics has been confirmed in several studies, however GAA utilization by CK seems to be a second-rate as compared to creatine, and compartment-dependent. Here we discuss various factors that might affect GAA use in high-energy phosphoryl transfer in the cytosol and mitochondria. | URI: | https://open.uns.ac.rs/handle/123456789/5962 | ISSN: | 0145-479X | DOI: | 10.1007/s10863-015-9619-7 |
Appears in Collections: | FSFV Publikacije/Publications |
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