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https://open.uns.ac.rs/handle/123456789/5482
Nаziv: | An advanced microencapsulated system: A platform for optimized oral delivery of antidiabetic drug-bile acid formulations | Аutоri: | Mooranian A. Negrulj R. Mathavan S. Martinez J. Sciarretta J. Chen-Tan N. Mukkur T. Momir Mikov Mladena Lalić-Popović Maja Stojančević Svetlana Goločorbin-Kon Al-Salami H. |
Ključnе rеči: | Artificial-cell microencapsulation;bile acids;diabetes;gliclazide | Dаtum izdаvаnjа: | 1-јан-2015 | Čаsоpis: | Pharmaceutical Development and Technology | Sažetak: | © 2015 Informa Healthcare USA, Inc. Introduction: In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G-CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition to G microcapsules in the morphology, structure and excipients' compatibility of the newly designed microcapsules. Method: Microencapsulation was carried out using our Buchi-based microencapsulating system developed in our laboratory. Using sodium alginate (SA) polymer, both formulations were prepared: G-SA (control) and G-CA-SA (test) at a constant ratio (1:3:30), respectively. Complete characterizations of microcapsules were carried out. Results: The new G-CA-SA formulation is further optimized by the addition of CA exhibiting pseudoplastic-thixotropic rheological characteristics. Bead size remains similar after CA addition, the new microcapsules show no chemical interactions between the excipients and this was supported further by the spectral studies suggesting bead stability. Conclusion: The new microencapsulated-formulation has good and uniform structural properties and may be suitable for oral delivery of antidiabetic-bile acid formulations. | URI: | https://open.uns.ac.rs/handle/123456789/5482 | ISSN: | 10837450 | DOI: | 10.3109/10837450.2014.915570 |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
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