Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке:
https://open.uns.ac.rs/handle/123456789/5482
Назив: | An advanced microencapsulated system: A platform for optimized oral delivery of antidiabetic drug-bile acid formulations | Аутори: | Mooranian A. Negrulj R. Mathavan S. Martinez J. Sciarretta J. Chen-Tan N. Mukkur T. Momir Mikov Mladena Lalić-Popović Maja Stojančević Svetlana Goločorbin-Kon Al-Salami H. |
Кључне речи: | Artificial-cell microencapsulation;bile acids;diabetes;gliclazide | Датум издавања: | 1-јан-2015 | Часопис: | Pharmaceutical Development and Technology | Сажетак: | © 2015 Informa Healthcare USA, Inc. Introduction: In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G-CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition to G microcapsules in the morphology, structure and excipients' compatibility of the newly designed microcapsules. Method: Microencapsulation was carried out using our Buchi-based microencapsulating system developed in our laboratory. Using sodium alginate (SA) polymer, both formulations were prepared: G-SA (control) and G-CA-SA (test) at a constant ratio (1:3:30), respectively. Complete characterizations of microcapsules were carried out. Results: The new G-CA-SA formulation is further optimized by the addition of CA exhibiting pseudoplastic-thixotropic rheological characteristics. Bead size remains similar after CA addition, the new microcapsules show no chemical interactions between the excipients and this was supported further by the spectral studies suggesting bead stability. Conclusion: The new microencapsulated-formulation has good and uniform structural properties and may be suitable for oral delivery of antidiabetic-bile acid formulations. | URI: | https://open.uns.ac.rs/handle/123456789/5482 | ISSN: | 10837450 | DOI: | 10.3109/10837450.2014.915570 |
Налази се у колекцијама: | MDF Publikacije/Publications |
Приказати целокупан запис ставки
SCOPUSTM
Навођења
49
проверено 10.05.2024.
Преглед/и станица
49
Протекла недеља
10
10
Протекли месец
2
2
проверено 10.05.2024.
Google ScholarTM
Проверите
Алт метрика
Ставке на DSpace-у су заштићене ауторским правима, са свим правима задржаним, осим ако није другачије назначено.