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https://open.uns.ac.rs/handle/123456789/349
Title: | Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease | Authors: | Jovanović, Ljiljana Vesna Subota Milena Stavrić Bojana Subotić Boris Džudović Nataša Novičić Jovan Matijašević Milica Mirić Sonja Salinger Nataša Marković-Nikolić Maja Nikolić Vladimir Miloradović Ljiljana Kos Tamara Kovačević-Preradović Jelena Marinković NIkola Kocev Slobodan Obradović |
Keywords: | Biomarkers;Brain natriuretic peptide;Mortality;Pulmonary embolism | Issue Date: | 1-May-2019 | Journal: | Clinica Chimica Acta | Abstract: | © 2019 Elsevier B.V. Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Blood concentrations of BNP, cTnI, CRP and D-dimer were measured during the first 24 h of hospitalization. BNP blood level had strong predictive value for the primary outcome in spontaneous PE (c-statistics 0.943, 95% CI 0.882–1.000, p = .001) and a slightly lower predictive outcome in provoked PE (c-statistics 0.824, 95% CI 0.745–0.902, p < .001). NRI and IDI showed that none of the markers, when added to BNP, could improve Cox regression prediction models for 30-day PE-related mortality in either the spontaneous or provoked PE group. Blood levels of BNP measured during the first 24 h of hospital admission had an excellent predictive value for 30-day PE-related mortality in spontaneous PE and slightly lower predictive value in provoked PE, whereas CRP, cTnI and D-Dimer did not contribute significantly to the predictive value of BNP in either group. | URI: | https://open.uns.ac.rs/handle/123456789/349 | ISSN: | 98981 | DOI: | 10.1016/j.cca.2019.02.008 |
Appears in Collections: | MDF Publikacije/Publications |
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