Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/349
DC Field | Value | Language |
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dc.contributor.author | Jovanović, Ljiljana | en_US |
dc.contributor.author | Vesna Subota | en_US |
dc.contributor.author | Milena Stavrić | en_US |
dc.contributor.author | Bojana Subotić | en_US |
dc.contributor.author | Boris Džudović | en_US |
dc.contributor.author | Nataša Novičić | en_US |
dc.contributor.author | Jovan Matijašević | en_US |
dc.contributor.author | Milica Mirić | en_US |
dc.contributor.author | Sonja Salinger | en_US |
dc.contributor.author | Nataša Marković-Nikolić | en_US |
dc.contributor.author | Maja Nikolić | en_US |
dc.contributor.author | Vladimir Miloradović | en_US |
dc.contributor.author | Ljiljana Kos | en_US |
dc.contributor.author | Tamara Kovačević-Preradović | en_US |
dc.contributor.author | Jelena Marinković | en_US |
dc.contributor.author | NIkola Kocev | en_US |
dc.contributor.author | Slobodan Obradović | en_US |
dc.date.accessioned | 2019-09-23T10:06:30Z | - |
dc.date.available | 2019-09-23T10:06:30Z | - |
dc.date.issued | 2019-05-01 | - |
dc.identifier.issn | 98981 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/349 | - |
dc.description.abstract | © 2019 Elsevier B.V. Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Blood concentrations of BNP, cTnI, CRP and D-dimer were measured during the first 24 h of hospitalization. BNP blood level had strong predictive value for the primary outcome in spontaneous PE (c-statistics 0.943, 95% CI 0.882–1.000, p = .001) and a slightly lower predictive outcome in provoked PE (c-statistics 0.824, 95% CI 0.745–0.902, p < .001). NRI and IDI showed that none of the markers, when added to BNP, could improve Cox regression prediction models for 30-day PE-related mortality in either the spontaneous or provoked PE group. Blood levels of BNP measured during the first 24 h of hospital admission had an excellent predictive value for 30-day PE-related mortality in spontaneous PE and slightly lower predictive value in provoked PE, whereas CRP, cTnI and D-Dimer did not contribute significantly to the predictive value of BNP in either group. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Clinica Chimica Acta | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Brain natriuretic peptide | en_US |
dc.subject | Mortality | en_US |
dc.subject | Pulmonary embolism | en_US |
dc.title | Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1016/j.cca.2019.02.008 | - |
dc.identifier.pmid | 492 | - |
dc.identifier.scopus | 2-s2.0-85061634751 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85061634751 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 83 | en_US |
dc.relation.firstpage | 78 | en_US |
dc.relation.volume | 492 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za zdravstvenu negu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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