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https://open.uns.ac.rs/handle/123456789/32631
Title: | Monitoring of Drug Release via Intra Body Communication with an Edible Pill | Authors: | Leonardo Lamanna Pietro Cataldi Marco Friuli Christian Demitri Mario Caironi |
Keywords: | edible electronics;intrabody communication;oleogel | Issue Date: | 26-Oct-2022 | Publisher: | Wiley-VCH | Project: | Twinning for reaching sustainable scientific and technological excellence in the field of Green Electronics (GREENELIT) | Journal: | Advanced Materials Technologies | Abstract: | Oral drug administration provides a convenient and patient-compliant way for drug delivery, especially for chronic diseases and prolonged pharmacological treatments. However, due to the repetitiveness of such therapeutic approach, the patients are led to neglect/forget the therapy affecting the healthcare delivery. Indeed, the non-adherence to pharmacological prescriptions and the unknown amount of real-time drug release result in a noncompliant therapeutic drug level over the protracted therapies. The proposed technology will enable the monitoring of both pharmacological adherence and real-time drug release. The approach exploits a passive intrabody communication (IBC) activation in order to enable an edible pill, realized starting from food additives and food-grade materials, to monitor pharmacological adherence. Following activation, the signal is modulated by IBC coupling switching triggered by pill degradation in a gastrointestinal tract, resulting in a monitored drug release. The proof-of-concept is designed for a targeted release and monitoring of Metformin in the intestine. The system shows an in vitro limit of cumulative drug release detection of 18 μg mL−1 and a limit of real-time drug release detection of 2 μg mL−1 min−1. This platform represents the first solution to monitor passive drug release in real-time, from intake to complete absorption, enabling unique and long-sought healthcare therapy and treatment opportunity. | URI: | https://open.uns.ac.rs/handle/123456789/32631 | ISSN: | 2365-709X | DOI: | https://doi.org/10.1002/admt.202200731 | Rights: | Attribution-NonCommercial-NoDerivs 3.0 United States |
Appears in Collections: | Projekti |
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Adv Materials Technologies - 2022 - Lamanna - Monitoring of Drug Release via Intra Body Communication with an Edible Pill.pdf | 1.46 MB | Adobe PDF | View/Open |
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