Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/32631
DC Field | Value | Language |
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dc.contributor.author | Leonardo Lamanna | en_US |
dc.contributor.author | Pietro Cataldi | en_US |
dc.contributor.author | Marco Friuli | en_US |
dc.contributor.author | Christian Demitri | en_US |
dc.contributor.author | Mario Caironi | en_US |
dc.date.accessioned | 2023-11-22T11:13:06Z | - |
dc.date.available | 2023-11-22T11:13:06Z | - |
dc.date.issued | 2022-10-26 | - |
dc.identifier.issn | 2365-709X | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/32631 | - |
dc.description.abstract | Oral drug administration provides a convenient and patient-compliant way for drug delivery, especially for chronic diseases and prolonged pharmacological treatments. However, due to the repetitiveness of such therapeutic approach, the patients are led to neglect/forget the therapy affecting the healthcare delivery. Indeed, the non-adherence to pharmacological prescriptions and the unknown amount of real-time drug release result in a noncompliant therapeutic drug level over the protracted therapies. The proposed technology will enable the monitoring of both pharmacological adherence and real-time drug release. The approach exploits a passive intrabody communication (IBC) activation in order to enable an edible pill, realized starting from food additives and food-grade materials, to monitor pharmacological adherence. Following activation, the signal is modulated by IBC coupling switching triggered by pill degradation in a gastrointestinal tract, resulting in a monitored drug release. The proof-of-concept is designed for a targeted release and monitoring of Metformin in the intestine. The system shows an in vitro limit of cumulative drug release detection of 18 μg mL−1 and a limit of real-time drug release detection of 2 μg mL−1 min−1. This platform represents the first solution to monitor passive drug release in real-time, from intake to complete absorption, enabling unique and long-sought healthcare therapy and treatment opportunity. | en_US |
dc.description.sponsorship | European Commission | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.relation | Twinning for reaching sustainable scientific and technological excellence in the field of Green Electronics (GREENELIT) | en_US |
dc.relation.ispartof | Advanced Materials Technologies | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | edible electronics | en_US |
dc.subject | intrabody communication | en_US |
dc.subject | oleogel | en_US |
dc.title | Monitoring of Drug Release via Intra Body Communication with an Edible Pill | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1002/admt.202200731 | - |
dc.description.version | Published | en_US |
dc.relation.firstpage | 2200731 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 8 | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.project.grantno | 951747 | - |
Appears in Collections: | Projekti |
Files in This Item:
File | Description | Size | Format | |
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Adv Materials Technologies - 2022 - Lamanna - Monitoring of Drug Release via Intra Body Communication with an Edible Pill.pdf | 1.46 MB | Adobe PDF | View/Open |
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