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https://open.uns.ac.rs/handle/123456789/3260
Nаziv: | Characterization of blood flow through intrapulmonary arteriovenous anastomoses and patent foramen ovale at rest and during exercise in stroke and transient ischemic attack patients | Аutоri: | Romac R. Otto Barak Glavas D. Susilovic Grabovac Z. Lozo P. Roje I. Caljkusic K. Drmic-Hofman I. Davis J. Dujic Z. Lovering A. |
Ključnе rеči: | exercise;polymorphisms;shunt;stroke;transient ischemic attack | Dаtum izdаvаnjа: | 1-мај-2017 | Čаsоpis: | Echocardiography | Sažetak: | © 2017, Wiley Periodicals, Inc. Objectives: We determined whether stroke and/or TIA subjects have exercise-induced blood flow through intrapulmonary arteriovenous anastomoses (QIPAVA) and/or patent foramen ovale (QPFO) and a genetic predisposition for ischemic stroke. Methods: Twenty-eight stroke and/or TIA subjects (33–63 years old) underwent transthoracic saline contrast echocardiography concomitant with transcranial Doppler to detect QIPAVA and QPFO at rest and during supine exercise with and without breathing 100% O2. We also examined genetic polymorphisms in FV Leiden (G1691A; rs6025), factor II (FII) prothrombin (G20210A; rs1799963), methylene tetrahydfropholate reductase (C677T, rs1801133), and plasminogen-activator inhibitor-1 (PAI-1) (4G/5G; rs1799889) and angiotensin-converting enzyme (ACE; I/D, rs4646994) in 24/28 subjects. Results: No subject without PFO had QIPAVA at rest (n=17), but 12/17 did with exercise. All PFO subjects had QPFO at rest (n=11) and 7/11 had either QIPAVA or QPFO with exercise. Breathing 100% O2 during exercise reduced or eliminated left heart contrast in all subjects. Gene analyses revealed that 15/24 patients were either heterozygous or homozygous for methylenetetrahydrofolate reductase gene polymorphism; 4G/4G and 4G/5G genotypes of plasminogen-activator inhibitor-1 were present in 7/24 and 13/24 patients, respectively; polymorphisms of ACE D/D genotype were present in 6/24 and I/D in 14/24 patients. Having both I/D and 4G/4G genotypes was more prevalent in PFO+ subjects (P=.03), and there was a trend (P=.06) for PFO− subjects to have a greater D/D genotype prevalence. Conclusions: Novel genetic predispositions reported here in PFO subjects should be investigated further in larger stroke and/or TIA patient datasets. | URI: | https://open.uns.ac.rs/handle/123456789/3260 | ISSN: | 0742-2822 | DOI: | 10.1111/echo.13519 |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
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