Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/3260
DC Field | Value | Language |
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dc.contributor.author | Romac R. | en_US |
dc.contributor.author | Otto Barak | en_US |
dc.contributor.author | Glavas D. | en_US |
dc.contributor.author | Susilovic Grabovac Z. | en_US |
dc.contributor.author | Lozo P. | en_US |
dc.contributor.author | Roje I. | en_US |
dc.contributor.author | Caljkusic K. | en_US |
dc.contributor.author | Drmic-Hofman I. | en_US |
dc.contributor.author | Davis J. | en_US |
dc.contributor.author | Dujic Z. | en_US |
dc.contributor.author | Lovering A. | en_US |
dc.date.accessioned | 2019-09-23T10:26:40Z | - |
dc.date.available | 2019-09-23T10:26:40Z | - |
dc.date.issued | 2017-05-01 | - |
dc.identifier.issn | 0742-2822 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/3260 | - |
dc.description.abstract | © 2017, Wiley Periodicals, Inc. Objectives: We determined whether stroke and/or TIA subjects have exercise-induced blood flow through intrapulmonary arteriovenous anastomoses (QIPAVA) and/or patent foramen ovale (QPFO) and a genetic predisposition for ischemic stroke. Methods: Twenty-eight stroke and/or TIA subjects (33–63 years old) underwent transthoracic saline contrast echocardiography concomitant with transcranial Doppler to detect QIPAVA and QPFO at rest and during supine exercise with and without breathing 100% O2. We also examined genetic polymorphisms in FV Leiden (G1691A; rs6025), factor II (FII) prothrombin (G20210A; rs1799963), methylene tetrahydfropholate reductase (C677T, rs1801133), and plasminogen-activator inhibitor-1 (PAI-1) (4G/5G; rs1799889) and angiotensin-converting enzyme (ACE; I/D, rs4646994) in 24/28 subjects. Results: No subject without PFO had QIPAVA at rest (n=17), but 12/17 did with exercise. All PFO subjects had QPFO at rest (n=11) and 7/11 had either QIPAVA or QPFO with exercise. Breathing 100% O2 during exercise reduced or eliminated left heart contrast in all subjects. Gene analyses revealed that 15/24 patients were either heterozygous or homozygous for methylenetetrahydrofolate reductase gene polymorphism; 4G/4G and 4G/5G genotypes of plasminogen-activator inhibitor-1 were present in 7/24 and 13/24 patients, respectively; polymorphisms of ACE D/D genotype were present in 6/24 and I/D in 14/24 patients. Having both I/D and 4G/4G genotypes was more prevalent in PFO+ subjects (P=.03), and there was a trend (P=.06) for PFO− subjects to have a greater D/D genotype prevalence. Conclusions: Novel genetic predispositions reported here in PFO subjects should be investigated further in larger stroke and/or TIA patient datasets. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Echocardiography | en_US |
dc.subject | exercise | en_US |
dc.subject | polymorphisms | en_US |
dc.subject | shunt | en_US |
dc.subject | stroke | en_US |
dc.subject | transient ischemic attack | en_US |
dc.title | Characterization of blood flow through intrapulmonary arteriovenous anastomoses and patent foramen ovale at rest and during exercise in stroke and transient ischemic attack patients | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1111/echo.13519 | - |
dc.identifier.pmid | 28317214 | - |
dc.identifier.scopus | 2-s2.0-85016231355 | - |
dc.identifier.isi | 000400027800007 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85016231355 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 682 | en_US |
dc.relation.firstpage | 676 | en_US |
dc.relation.issue | 5 | en_US |
dc.relation.volume | 34 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za fiziologiju | - |
crisitem.author.orcid | 0000-0001-6727-8304 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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