Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/32537
Nаziv: | Graphene oxide role in Bacterial cellulose/gelatin crosslinked hydrogels for wound dressing applications | Аutоri: | Muhammad Umar Aslam Khan Goran Stojanović Rozita Hassan Anand Sahaya T. Joseph Maryam Al-Ejji Anwarul Hasan |
Ključnе rеči: | Graphene Oxide;Gelatin Crosslinked Hydrogels;Wound Dressing | Dаtum izdаvаnjа: | 27-мар-2023 | Izdаvаč: | ACS - American Ceramic Society | Prојеkаt: | GREENELIT | Čаsоpis: | ACS Omega | Sažetak: | Biopolymer-based hydrogels have several advantages, including robust mechanical, high biocompatibility, and excellent properties. These hydrogels can be ideal wound dressing materials and advantageous to repair and regenerate skin wounds. In this work, we have reported fabricated of composite hydrogels from gelatin and graphene oxide-functionalized-bacterial cellulose (synthesized by hydrothermal method) (GO-f-BC) and crosslinked with tetraethyl orthosilicate (TEOS). The hydrogels were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, and water contact angle analyses to explore functional groups and their interactions, surface morphology, and wetting behavior, respectively. The swelling, biodegradation, and water retention were tested to respond to biofluid. Maximum swelling was exhibited by samle with maximum amount of GO (GBG-4) in all media (aqueous = 1902.83%, PBS = 1546.63%, and electrolyte = 1367.32%). The hemolysis of all hydrogel samples is less than 0.5%, and the blood coagulation time decreased as the hydrogel concentration increased. The composite hydrogels were found to be hemocompatible as they have less than 0.5% hemolysis for all hydrogel samples under in vitro standard conditions. These hydrogels performed unusual antimicrobial activities against Gram (positive and negative) bacterial strains. The cell viability and proliferation were increased with an increased GO amount, and maximum values were found for GBG-4 against fibroblast (3T3) cell lines. The mature and well-adhered cell morphology of 3T3 cells was found against all hydrogel samples. Hence, based on these results findings, these hydrogels would be potential wound dressing skin materials for wound healing applications. | URI: | https://open.uns.ac.rs/handle/123456789/32537 | ISSN: | 2470-1343 | DOI: | https://doi.org/10.1021/acsomega.2c07279 | Prаvа: | Attribution-NonCommercial-NoDerivs 3.0 United States |
Nаlаzi sе u kоlеkciјаmа: | FTN Publikacije/Publications |
Dаtоtеkе u оvој stаvci:
Dаtоtеkа | Оpis | Vеličinа | Fоrmаt | |
---|---|---|---|---|
ACS Omega Umar Khun.pdf | Graphene Oxide | 12.9 MB | Adobe PDF | Pоglеdајtе |
Prеglеd/i stаnicа
65
Prоtеklа nеdеljа
16
16
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Prеuzimаnjе/а
68
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Оvа stаvkа је licеncirаnа pоd Krеаtivnа dоzvоlа grаđаnа