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Title: Latent, genetic, and molecular genetic structure of the Wisconsin Card Sorting Test
Authors: Željka Nikolašević 
Vojislava Bugarski Ignjatović 
Jasmina Kodžopeljić 
Selka Sadiković 
Ilija Milovanović 
Nataša Vučinić 
Mechthild Prinz
Zoran Budimlija
Snežana Smederevac 
Keywords: behavioral genetics;WCST;COMT;DRD2;BDNF
Issue Date: May-2022
Publisher: American Psychological Association
Source: Nikolašević, Ž., Bugarski Ignjatović, V., Kodžopeljić, J., Sadiković, S., Milovanović, I., Vučinić, N., Prinz, M., Budimlija, Z., & Smederevac, S. (2022). Latent, genetic, and molecular genetic structure of the Wisconsin Card Sorting Test. Neuropsychology, 36(4), 314–329.
Project: This research was supported by the Science Fund of the Republic of Serbia (#7744418 GENIUS).
Journal: Neuropsychology
Abstract: Objective: The main goal of this study was to explore the latent structure and genetic basis of cognitive processes involved in the Wisconsin Card Sorting Task (WCST) within phenotypic, behavioral genetic, and molecular genetic research paradigms. Method: The sample used in phenotypic and behavioral genetic analyses comprised 468 twins (154 monozygotic and 80 dizygotic twin pairs), while molecular genetic analyses were performed on 404 twins from the same sample. The zygosity of most twin pairs (96.8%) was determined via DNA analysis of buccal swabs. Trained researchers administered the Wisconsin Card Sorting Test – WCST (Heaton et al., 1993) to the entire sample. Results: A phenotypic factor analysis of WCST variables suggested a single-factor solution. Overall heritability ranged from 0.19 to 0.23 across different measures of the WCST. The presence of a single general genetic factor, which could be identified from different measures of the WCST, indicated the unity of various WCST indicators and the existence of a common basic ability. Performance on the WCST did not reveal significant differences between the three genotypes on COMT and DRD2. Carriers of the BDNF Met+ genotype exhibited better performance in cognitive functions in comparison to the BDNF Met- genotype. Conclusions: This study highlighted similarities in the phenotypic and genetic structures of the WCST, suggesting one general factor underlying different cognitive functions. The BDNF Met + genotype showed significant main effects on different WCST measures.
ISSN: 0894-4105
DOI: DOI: 10.1037/neu0000800
Appears in Collections:Naučne i umetničke publikacije

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