Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/32461
Title: Microfluidic Approach for Measurements of pH, O2, and CO2 in Saliva
Authors: Podunavac, Ivana 
Hinić, Stevan
Kojić, Sanja 
Jelenciakova, Nina
Radonić, Vasa 
Petrović, Bojan 
Stojanović, Goran 
Keywords: saliva;microfluidics;sensors;pH;oxygen;carbon dioxide
Issue Date: Feb-2021
Publisher: MYU K.K. Tokyo
Project: H2020 SALSETH
Journal: Sensors and Materials
Abstract: In this paper, we propose a microfluidic approach for measuring pH, dissolved oxygen (O2), and carbon dioxide (CO2) in human saliva. The proposed innovative method combines the advantages of a microfluidic approach, i.e., small amounts of samples and reagents and precise control of the experimental conditions, with rapid measurements of significant parameters of saliva. The novel design of a microfluidic chip with integrated commercially available PreSens sensors was used for examining the effect of Chlorhexidine on artificial saliva (AS), stimulated saliva (SS), and non-stimulated saliva (NSS). The measurement results showed that for persons with an initially low saliva pH, the use of Chlorhexidie increased the pH, and afterward, the pH value returned to the initial value or higher. However, measurements of volunteers with initial pH close to neutral showed that Chlorhexidine reduced the pH value, increasing the risk of erosion and demineralization. In conclusion, the proposed methodology showed potential for precise measurements of pH in saliva samples; however, further research is required to examine the influence of the sample collection method on the amounts of O2 and CO2 in saliva.
URI: https://open.uns.ac.rs/handle/123456789/32461
ISSN: 0914-4935
DOI: 10.18494/SAM.2021.3219
Rights: Attribution-NonCommercial-NoDerivs 3.0 United States
Appears in Collections:FTN Publikacije/Publications
IBS Publikacije/Publications

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