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https://open.uns.ac.rs/handle/123456789/32457
Title: | A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds | Authors: | Armin Mooranian Nassim Zamani Momir Mikov Svetlana Goločorbin-Kon Goran Stojanović Frank Arfuso Božica Kovačević Hani Al-Salami |
Keywords: | Probucol;Microencapsulation;Eudragit;Alginate;oral delivery;Diabetes mellitus | Issue Date: | 7-Dec-2019 | Publisher: | Saudi Pharmaceutical Society | Project: | H2020 SALSETH | Journal: | Saudi Pharmaceutical Journal | Abstract: | Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have b-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and antiinflammatory drugs, such as probucol (PB). Thus, this study aimed to design and test microcapsules containing a PUBA incorporated with PB and an alginate-Eudragit matrix. Six types of microcapsules were developed without (control) or with (test) PUBA, and tested for internal and external features and b-cell protective effects. The incorporation of PB-alginate-Eudragit with PUBA produced stable microcapsules but did not exert consistent positive effects on cell viability in the hyperglycaemic state, which suggests that PUBA in alginate-Eudragit matrices did not exhibit synergistic effects with PB nor exerted antidiabetic effects. | URI: | https://open.uns.ac.rs/handle/123456789/32457 | ISSN: | 1319-0164 | DOI: | https://doi.org/10.1016/j.jsps.2019.11.017 | Rights: | Attribution-NonCommercial-NoDerivs 3.0 United States |
Appears in Collections: | FTN Publikacije/Publications |
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1-s2.0-S1319016419301689-main.pdf | 1.38 MB | Adobe PDF | View/Open |
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