Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/32451
Title: | Pharmacological Effects of Secondary Bile Acid Microparticles in Diabetic Murine Model | Authors: | Armin Mooranian Nassim Zamani Božica Kovačević Corina Mihaela Ionescu Giuseppe Luna Momir Mikov Svetlana Goločorbin-Kon Goran Stojanović Sanja Kojić Hani Al-Salami |
Keywords: | Lithocholic acid;metabolites;bile acid profile;diabetes;type 2 diabetes mellitus;nanocapsules | Issue Date: | 5-Jun-2020 | Publisher: | Bentham Science | Project: | H2020 SALSETH | Journal: | Current Diabetes Reviews | Abstract: | Abstract: Aim: Examine bile acids effects in Type 2 diabetes. Background: In recent studies, the bile acid ursodeoxycholic acid (UDCA) has shown potent anti inflammatory effects in obese patients while in type 2 diabetics (T2D) levels of the pro-inflammatory bile acid lithocholic acid were increased, and levels of the anti-inflammatory bile acid chenodeoxycholic acid were decreased, in plasma. Objective: Hence, this study aimed to examine applications of novel UDCA microparticles in diabetes. Methods: Diabetic balb/c adult mice were divided into three equal groups and gavaged daily with either empty microcapsules, free UDCA, or microencapsulated UDCA over two weeks. Their blood, tissues, urine, and faeces were collected for blood glucose, inflammation, and bile acid analyses. UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Results: UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Conclusion: Bile acids modulated the bile profile without affecting blood glucose levels. | URI: | https://open.uns.ac.rs/handle/123456789/32451 | ISSN: | 1875-6417 | DOI: | 10.2174/1573399816666200626213735 | Rights: | Attribution-NonCommercial-NoDerivs 3.0 United States |
Appears in Collections: | FTN Publikacije/Publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
D0010D.pdf | 23.38 MB | Adobe PDF | View/Open |
Page view(s)
27
Last Week
1
1
Last month
0
0
checked on May 10, 2024
Download(s)
25
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
This item is licensed under a Creative Commons License