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https://open.uns.ac.rs/handle/123456789/31422
Nаziv: | Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen | Аutоri: | Novković Luka Trmčić Milena Rodić Marko Bihelović Filip Zlatar Matija Matović Radomir Saičić Radomir Nikola |
Dаtum izdаvаnjа: | 2015 | Čаsоpis: | RSC Advances | Sažetak: | A new Zn(II)-based potential chemotherapeutic agent was synthesized from the ligand 2-quinolinecarboxaldehyde selenosemicarbazone (Hqasesc). Single crystal X-ray diffraction analysis showed that the Zn(II) complex consists of a cation [Zn(Hqasesc)2]2+, two perchlorate anions and one ethanol solvent molecule. The interaction of calf thymus (CT) DNA and human serum albumin (HSA) with the Zn(II) complex was explored using absorption and emission spectral methods, and also has been supported by molecular docking studies. The complex has more affinity to minor DNA groove than major, with no significant intercalation. The HSA interaction studies of the complex revealed the quenching of the intrinsic fluorescence of the HSA through a static quenching mechanism. The antitumor activity of the ligand and the complex against pancreatic adenocarcinoma cell line (AsPC-1) and acute monocytic leukemia (THP-1) cells was evaluated. Both compounds are strong concentration-dependent apoptosis inducers in THP-1 cells. While Hqasesc in AsPC-1 cells induces apoptosis only at the highest concentration, treatment with the Zn complex shows a concentration-dependent apoptotic response, where the treated cells are arrested in the G1-to-S phase accompanied with extensive activation of caspase-8 and -9. These results indicate that the ligand and Zn(II) complex display cell phenotype specific activity. | URI: | https://open.uns.ac.rs/handle/123456789/31422 | ISSN: | 2046-2069 | DOI: | 10.1039/C5RA13476E |
Nаlаzi sе u kоlеkciјаmа: | PMF Publikacije/Publications |
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