Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/31422
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Novković Luka | - |
dc.contributor.author | Trmčić Milena | - |
dc.contributor.author | Rodić Marko | - |
dc.contributor.author | Bihelović Filip | - |
dc.contributor.author | Zlatar Matija | - |
dc.contributor.author | Matović Radomir | - |
dc.contributor.author | Saičić Radomir Nikola | - |
dc.date.accessioned | 2020-12-14T20:00:07Z | - |
dc.date.available | 2020-12-14T20:00:07Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/31422 | - |
dc.description.abstract | A new Zn(II)-based potential chemotherapeutic agent was synthesized from the ligand 2-quinolinecarboxaldehyde selenosemicarbazone (Hqasesc). Single crystal X-ray diffraction analysis showed that the Zn(II) complex consists of a cation [Zn(Hqasesc)2]2+, two perchlorate anions and one ethanol solvent molecule. The interaction of calf thymus (CT) DNA and human serum albumin (HSA) with the Zn(II) complex was explored using absorption and emission spectral methods, and also has been supported by molecular docking studies. The complex has more affinity to minor DNA groove than major, with no significant intercalation. The HSA interaction studies of the complex revealed the quenching of the intrinsic fluorescence of the HSA through a static quenching mechanism. The antitumor activity of the ligand and the complex against pancreatic adenocarcinoma cell line (AsPC-1) and acute monocytic leukemia (THP-1) cells was evaluated. Both compounds are strong concentration-dependent apoptosis inducers in THP-1 cells. While Hqasesc in AsPC-1 cells induces apoptosis only at the highest concentration, treatment with the Zn complex shows a concentration-dependent apoptotic response, where the treated cells are arrested in the G1-to-S phase accompanied with extensive activation of caspase-8 and -9. These results indicate that the ligand and Zn(II) complex display cell phenotype specific activity. | - |
dc.language.iso | en | - |
dc.relation.ispartof | RSC Advances | - |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.title | Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen | - |
dc.type | Journal/Magazine Article | - |
dc.identifier.doi | 10.1039/C5RA13476E | - |
dc.identifier.scopus | 2-s2.0-84948440550 | - |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=97191&source=BEOPEN&language=en | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84948440550 | - |
dc.relation.lastpage | 99584 | - |
dc.relation.firstpage | 99577 | - |
dc.relation.issue | 120 | - |
dc.relation.volume | 5 | - |
dc.identifier.externalcrisreference | (BISIS)97191 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.orcid | 0000-0002-4471-8001 | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
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