Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/28902| Title: | Synthesis and biological activity of 17-substituted androstane derivatives Sinteza i biološka aktivnost 17-supstituisanih androstanskih derivata |
Authors: | Ajduković Jovana | Keywords: | Synthesis, steroids, androstane derivatives, antiproliferative activity;Sinteza, steroidi, derivati androstana, antiproliferativna aktivnost | Issue Date: | 8-Oct-2013 | Publisher: | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu University of Novi Sad, Faculty of Sciences at Novi Sad |
Abstract: | <p>U prvom delu ove doktorske disertacije je izvršena sinteza novih 17α-pikolil i 17(E)-pikoliniliden androstanskih derivata, sa modifikacijama u A- i/ili B-prstenovima. U drugom delu rada je ispitana antiproliferativna aktivnost odabranih novosintetizovanih jedinjenja prema humanim tumorskim ćelijskim linijama (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29 i A549) kao i prema zdravim ćelijama fetalnih fibroblasta pluća (MRC-5).</p> <p>In the first part of this dissertation, the synthesis of new 17α-picolyl and 17(E)-picolinylidene androstane derivatives with modifications in A and/or B rings, were presented. The second part of the work consisted on investigation of antiproliferative activity of selected newly synthesized compounds toward human carcinoma cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29 and A549), as well as the healthy fetal lung fibroblasts (MRC-5).</p> |
URI: | https://open.uns.ac.rs/handle/123456789/28902 | DOI: | 10.2298/NS20131008AJDUKOVIC |
| Appears in Collections: | PMF Teze/Theses |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.