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https://open.uns.ac.rs/handle/123456789/28232| Title: | Synthesis and antiproliferative activity of new D-homo and D-seco androstane derivatives Sinteza i antiproliferativna aktivnost novih D-homo i D-seko derivata androstana |
Authors: | Savić Marina P. | Keywords: | Synthesis, steroids, androstane derivatives, antiproliferative activity;Sinteza, steroidi, derivati androstana, antiproliferativna aktivnost | Issue Date: | 19-Mar-2013 | Publisher: | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu University of Novi Sad, Faculty of Sciences at Novi Sad |
Abstract: | <p>U prvom delu ove doktorske disertacije je izvršena<br />sinteza novih derivata androstana sa D-laktonskom<br />funkcijom ili D-seko derivata, sa modifikacijama u Ai/<br />ili B-prstenovima. U drugom delu je ispitana<br />antiproliferativna aktivnost odabranih<br />novosintetizovanih jedinjenja prema humanim<br />tumorskim ćelijskim linijama (MCF-7, MDA-MB-231,<br />PC-3, HeLa, HT-29, K562) kao i prema zdravim<br />ćelijama fetalnih fibroblasta pluća (MRC-5).</p> <p>In first part of this work was achieved synthesis of some new androstane derivatives with D-lactone function and new D-seco derivatives with modification in A and/or B rings. In the second part the antiproliferative activity of selected newly synthesized compounds by human carcinoma cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29, K562) and the healthy cells of fetal lung fibroblasts (MRC-5 ) was examined.</p> |
URI: | https://open.uns.ac.rs/handle/123456789/28232 | DOI: | 10.2298/NS20130319SAVIC |
| Appears in Collections: | PMF Teze/Theses |
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