Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/27373| Title: | Sinteza i biološka aktivnost novih analoga tiazofurina Synthesis and Biological Activity of New Tiazofurin Analogues |
Authors: | Torović Ljiljana | Keywords: | sinteza, novi analozi tiazofurina, biološka aktivnost;Synthesis, new tiazofurine analogues, biological activity | Issue Date: | 23-Jun-2004 | Publisher: | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu University of Novi Sad, Faculty of Sciences at Novi Sad |
Abstract: | <p>U radu je ostvarena višefazna sinteza novih analoga tiazofurina sa fluoro, azido ili različitim amido grupama u šećernom segmentu nukleozida, polazeći od D-glukoze, preko odabranih 2,5-anhidro heksoza kao ključnih intermedijera. In vitro je ispitana citotksična aktivnost novosintetizovanih nukleozida protiv različitih ćelijskih linija humane leukemije i čvrstih tumora.</p> <p>Multi-step syntheses of new analouges of tiazofurin with fluoro, azido or different amido groups in carbohydrate moiety of nucleosides, has been achieved starting from D-glucose, by use of selected 2,5-anhydro sugar derivatives as key intermediates. All nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.</p> |
URI: | https://open.uns.ac.rs/handle/123456789/27373 | Rights: |
| Appears in Collections: | PMF Teze/Theses |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.