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https://open.uns.ac.rs/handle/123456789/27369| Title: | Stereospecifična sinteza (+) -muskarina i njegovih biološki aktivnih stereoziomera iz D-glukoze Stereospecific Synthesis of (+)/Muscarine and its Biologically Active Stereoisomers from d-Glucose |
Authors: | Berić Ostoja | Keywords: | Stereospecifična sinteza, (+)-muskarin, analozi, D-glukoza;Stereospecific synthesis, (+)-muscarine, analogues, D-glucose, chiral synthon | Issue Date: | 26-Dec-1996 | Publisher: | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu University of Novi Sad, Faculty of Sciences at Novi Sad |
Abstract: | <p>U radu su ostvarene sinteze (+)-muskarina i njegovih biološki aktivnih stereoizomera, (+)-<em>epialo</em>-muskarina. (+)-<em>epi</em>-muskarina i (-)-<em>alo</em>-muskarina, zasnovane na konceptu hiralnih templata i na D-glukozi kao hiralnom prekursoru. Pri tome su sve neophodne hemijske transformacije hiralnog prekursora izvedene u potpunosti stereo-hemo- i regio-specigično, što je rezultovalo dobijanjem svih intermedijera i konačnih proizvoda u enantiomerno čistoj formi.</p> <p>Stereospecific synthesis of (+)-muscarine and its biologically active stereoisomers (+)-<em>(+)</em>(+)-<em>epiallo-</em>muscarine, (+)-epi-muscarine and (-)-allo-muscarine have been achieved by using the concept of chiral templates and D-glucose as a chiral precursor. All chemo- and regio-specifically,whereupon all the key intermediates as well as the final products were pbtained in enantiomerically pure form.</p> |
URI: | https://open.uns.ac.rs/handle/123456789/27369 | Rights: |
| Appears in Collections: | PMF Teze/Theses |
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