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https://open.uns.ac.rs/handle/123456789/2697
Title: | Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women | Authors: | Korovljev, Darinka Trivić, Tatjana Drid, Patrik Ostojić, Sergej |
Keywords: | Mitochondrial dysfunction;Molecular hydrogen;Obesity | Issue Date: | 2018 | Journal: | Irish Journal of Medical Science | Abstract: | Background: Molecular hydrogen (H 2 ) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H 2 for improving biomarkers of obesity in humans. Aim: In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H 2 intervention on body composition, hormonal status, and mitochondrial function in ten (n = 10) middle-aged overweight women. Methods: Volunteers received either hydrogen-generating minerals (supplying ~6 ppm of H 2 per day) or placebo by oral administration of caplets for 4 weeks. The primary end-point of treatment efficacy was the change in the body fat percentage from baseline to 4 weeks. In addition, assessment of other body composition indices, screening laboratory studies, and evaluation of side effects were performed before and at follow-up. Clinical trial registration www.clinicaltrials.gov, ID number NCT02832219. Results: No significant differences were observed between treatment groups for changes in weight, body mass index, and body circumferences at 4-week follow-up (P > 0.05). H 2 treatment significantly reduced body fat percentage (3.2 vs. 0.9%, P = 0.05) and arm fat index (9.7 vs. 6.0%, P = 0.01) compared to placebo administration, respectively. This was accompanied by a significant drop in serum triglycerides after H 2 intervention comparing to placebo (21.3 vs. 6.5%; P = 0.04), while other blood lipids remained stable during the study (P > 0.05). Fasting serum insulin levels dropped by 5.4% after H 2 administration, while placebo intervention augmented insulin response by 29.3% (P = 0.01). Conclusions: It appears that orally administered H 2 as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity. | URI: | https://open.uns.ac.rs/handle/123456789/2697 | ISSN: | 211265 | DOI: | 10.1007/s11845-017-1638-4 |
Appears in Collections: | FSFV Publikacije/Publications |
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