Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/2697
DC Field | Value | Language |
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dc.contributor.author | Korovljev, Darinka | en_US |
dc.contributor.author | Trivić, Tatjana | en_US |
dc.contributor.author | Drid, Patrik | en_US |
dc.contributor.author | Ostojić, Sergej | en_US |
dc.date.accessioned | 2019-09-23T10:23:08Z | - |
dc.date.available | 2019-09-23T10:23:08Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 211265 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/2697 | - |
dc.description.abstract | Background: Molecular hydrogen (H 2 ) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H 2 for improving biomarkers of obesity in humans. Aim: In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H 2 intervention on body composition, hormonal status, and mitochondrial function in ten (n = 10) middle-aged overweight women. Methods: Volunteers received either hydrogen-generating minerals (supplying ~6 ppm of H 2 per day) or placebo by oral administration of caplets for 4 weeks. The primary end-point of treatment efficacy was the change in the body fat percentage from baseline to 4 weeks. In addition, assessment of other body composition indices, screening laboratory studies, and evaluation of side effects were performed before and at follow-up. Clinical trial registration www.clinicaltrials.gov, ID number NCT02832219. Results: No significant differences were observed between treatment groups for changes in weight, body mass index, and body circumferences at 4-week follow-up (P > 0.05). H 2 treatment significantly reduced body fat percentage (3.2 vs. 0.9%, P = 0.05) and arm fat index (9.7 vs. 6.0%, P = 0.01) compared to placebo administration, respectively. This was accompanied by a significant drop in serum triglycerides after H 2 intervention comparing to placebo (21.3 vs. 6.5%; P = 0.04), while other blood lipids remained stable during the study (P > 0.05). Fasting serum insulin levels dropped by 5.4% after H 2 administration, while placebo intervention augmented insulin response by 29.3% (P = 0.01). Conclusions: It appears that orally administered H 2 as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity. | en_US |
dc.relation.ispartof | Irish Journal of Medical Science | en_US |
dc.subject | Mitochondrial dysfunction | en_US |
dc.subject | Molecular hydrogen | en_US |
dc.subject | Obesity | en_US |
dc.title | Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1007/s11845-017-1638-4 | - |
dc.identifier.pmid | 187 | - |
dc.identifier.scopus | 2-s2.0-85019662310 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85019662310 | - |
dc.description.version | Unknown | en_US |
dc.relation.lastpage | 89 | en_US |
dc.relation.firstpage | 85 | en_US |
dc.relation.volume | 187 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Fakultet sporta i fizičkog vaspitanja | - |
crisitem.author.dept | Кatedra za individualne sportove | - |
crisitem.author.dept | Кatedra za individualne sportove | - |
crisitem.author.dept | Кatedra za primenjene sportske nauke | - |
crisitem.author.orcid | 0000-0002-7270-2541 | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
crisitem.author.parentorg | Fakultet sporta i fizičkog vaspitanja | - |
crisitem.author.parentorg | Fakultet sporta i fizičkog vaspitanja | - |
crisitem.author.parentorg | Fakultet sporta i fizičkog vaspitanja | - |
Appears in Collections: | FSFV Publikacije/Publications |
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