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Title: | Functional role of Ca<sup>2+</sup> currents within the stereocilia as bio-MEMS: A modeling study | Authors: | Sekulić, Dalibor Sataric M. Joža, Ana |
Issue Date: | 12-Dec-2017 | Journal: | Proceedings of the International Conference on Microelectronics, ICM | Abstract: | © 2017 IEEE. Hair cells are thought to be passive transduction systems able to convert a mechanical pulse in an electrical signal. In this paper, we have investigated the polyelectrolyte properties of actin filaments which in interaction with myosin motor proteins represent basic participants in mechano-electrical transduction in the stereocilia, mechanosensing organelles of hair cells. We have elaborated a biophysical model with the aim to explain how actin filaments play the role of guides for propagation of Ca2+ ion currents. Special emphasis is placed on the possible role of this mechanism in tuning the activity of myosin motors which are involved in mechanosensitivity of the stereocilia. | URI: | https://open.uns.ac.rs/handle/123456789/2311 | ISBN: | 9781538625637 | DOI: | 10.1109/MIEL.2017.8190070 |
Appears in Collections: | FTN Publikacije/Publications |
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