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https://open.uns.ac.rs/handle/123456789/17439
Назив: | Chromatographic lipophilicity as a predictor of antiproliferative activity of 17-picolyl and 17-picolinylidene androstane derivatives toward prostate cancer | Аутори: | Kovačević, Strahinja Podunavac-Kuzmanović, Sanja Jevrić, Lidija Đurendić, Evgenija Ajduković (Daljev), Jovana Jovanov, Pavle |
Кључне речи: | Prostate cancer;chemometrics;chromatography;lipophilicity;molecular modeling | Датум издавања: | 1-дец-2015 | Издавач: | Novi Sad: University of Novi Sad, Faculty of Technology, Novi Sad | Часопис: | Acta Periodica Technologica | Сажетак: | The present study describes the quantitative retention - (anticancer) activity relationship analysis of a series of 17-picolyl and 17-picolinylidene androstane derivatives based on the chromatographic data obtained by reversed-phase high performance liquid chromatography (C18-RP-HPLC) in a mobile phase consisting of 90% of methanol and 10% of water. The obtained retention factor or chromatographic lipophilicity factor (logk0.90) was correlated with the antiproliferative activity of studied compounds (IC50) toward androgen-receptor negative prostate cancer cell line (AR-neg. PC-3). Correlation analysis was carried out by applying non-linear artificial neural networks (ANNs) method. Statistical validation showed that the obtained ANNs can successfully predict the IC50 values of structurally similar androstane derivatives. | URI: | https://open.uns.ac.rs/handle/123456789/17439 | ISSN: | 1450-7188 | DOI: | 10.2298/APT1546239K (BISIS)103749 (BISIS)103749 |
Налази се у колекцијама: | FINS Publikacije/Publications TF Publikacije/Publications |
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