Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке: https://open.uns.ac.rs/handle/123456789/16774
Назив: Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: Synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction
Аутори: Filipović Nenad
Bjelogrlic Snežana
Marinković Aleksandar
Verbić Tatjana
Cvijetić Ilija
Senćanski Milan
Rodić Marko 
Vujčić Miroslava
Sladić Dušan
Strikovic Zlatko
Todorović Tamara
Muller Christian
Датум издавања: 2015
Часопис: RSC Advances
Сажетак: © 2015 The Royal Society of Chemistry. A new Zn(ii)-based potential chemotherapeutic agent was synthesized from the ligand 2-quinolinecarboxaldehyde selenosemicarbazone (Hqasesc). Single crystal X-ray diffraction analysis showed that the Zn(ii) complex consists of a cation [Zn(Hqasesc)2]2+, two perchlorate anions and one ethanol solvent molecule. The interaction of calf thymus (CT) DNA and human serum albumin (HSA) with the Zn(ii) complex was explored using absorption and emission spectral methods, and also has been supported by molecular docking studies. The complex has more affinity to minor DNA groove than major, with no significant intercalation. The HSA interaction studies of the complex revealed the quenching of the intrinsic fluorescence of the HSA through a static quenching mechanism. The antitumor activity of the ligand and the complex against pancreatic adenocarcinoma cell line (AsPC-1) and acute monocytic leukemia (THP-1) cells was evaluated. Both compounds are strong concentration-dependent apoptosis inducers in THP-1 cells. While Hqasesc in AsPC-1 cells induces apoptosis only at the highest concentration, treatment with the Zn complex shows a concentration-dependent apoptotic response, where the treated cells are arrested in the G1-to-S phase accompanied with extensive activation of caspase-8 and -9. These results indicate that the ligand and Zn(ii) complex display cell phenotype specific activity.
URI: https://open.uns.ac.rs/handle/123456789/16774
ISSN: 2046-2069
DOI: 10.1039/C5RA19849F
Налази се у колекцијама:PMF Publikacije/Publications

Приказати целокупан запис ставки

SCOPUSTM   
Навођења

33
проверено 20.11.2023.

Преглед/и станица

21
Протекла недеља
6
Протекли месец
0
проверено 10.05.2024.

Google ScholarTM

Проверите

Алт метрика


Ставке на DSpace-у су заштићене ауторским правима, са свим правима задржаним, осим ако није другачије назначено.