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https://open.uns.ac.rs/handle/123456789/16293
Назив: | Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid | Аутори: | Mooranian, A. Zamani, N. Momir Mikov Svetlana Goločorbin-Kon Stojanović, Goran Arfuso, F. Al-Salami, H. |
Кључне речи: | probucol;Microencapsulation;Deoxycholic acid | Датум издавања: | 23-авг-2018 | Пројекат: | MEDLEM | Часопис: | Therapeutic Delivery | Сажетак: | Aim: Deoxycholic acid (DCA) has improved gliclazide oral absorption, while Eudragit® (ED) polymers have improved formulation stability of antidiabetic drugs. The aim of the study is to test if DCA and ED encapsulation will optimize the release and stability of the potential antidiabetic drug probucol (PB). Materials & methods: The PB formulations were prepared using ED polymers and DCA, and formulations were analyzed for their rheological and biological properties. Results: Rheological properties and size distribution were similar among all groups. ß-cell survival and biological activities were best with NM30D microcapsules. The inflammatory profile and oxidative stress effects of microcapsules remained similar among all groups. Conclusion: ED NM30D and DCA incorporation can exert positive and stabilizing effects on PB oral microcapsules | URI: | https://open.uns.ac.rs/handle/123456789/16293 | ISSN: | 2041-5990 | DOI: | 10.4155/tde-2018-0036 | Права: | Attribution-NonCommercial-ShareAlike 3.0 United States |
Налази се у колекцијама: | FTN Publikacije/Publications |
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Eudragit®-based microcapsules of probucol.pdf | 401.48 kB | Adobe PDF | Погледајте |
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Ова ставка је лиценцирана под Креативна дозвола грађана