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https://open.uns.ac.rs/handle/123456789/1600
Nаziv: | Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: A European LeukemiaNet study | Аutоri: | Stauder R. Yu G. Koinig K. Bagguley T. Fenaux P. Symeonidis A. Sanz G. Cermak J. Mittelman M. Hellström-Lindberg E. Langemeijer S. Holm M. Madry K. Malcovati L. Tatic A. Germing U. Aleksandar Savić Van Marrewijk C. Guerci-Bresler A. Luño E. Droste J. Efficace F. Smith A. Bowen D. De Witte T. |
Ključnе rеči: | myelodysplastic syndromes;health-related quality of life | Dаtum izdаvаnjа: | 1-јун-2018 | Čаsоpis: | Leukemia | Sažetak: | © 2018 The Author(s). In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospecive data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations. | URI: | https://open.uns.ac.rs/handle/123456789/1600 | ISSN: | 8876924 | DOI: | 10.1038/s41375-018-0089-x |
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