Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/1600
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Stauder R. | en_US |
dc.contributor.author | Yu G. | en_US |
dc.contributor.author | Koinig K. | en_US |
dc.contributor.author | Bagguley T. | en_US |
dc.contributor.author | Fenaux P. | en_US |
dc.contributor.author | Symeonidis A. | en_US |
dc.contributor.author | Sanz G. | en_US |
dc.contributor.author | Cermak J. | en_US |
dc.contributor.author | Mittelman M. | en_US |
dc.contributor.author | Hellström-Lindberg E. | en_US |
dc.contributor.author | Langemeijer S. | en_US |
dc.contributor.author | Holm M. | en_US |
dc.contributor.author | Madry K. | en_US |
dc.contributor.author | Malcovati L. | en_US |
dc.contributor.author | Tatic A. | en_US |
dc.contributor.author | Germing U. | en_US |
dc.contributor.author | Aleksandar Savić | en_US |
dc.contributor.author | Van Marrewijk C. | en_US |
dc.contributor.author | Guerci-Bresler A. | en_US |
dc.contributor.author | Luño E. | en_US |
dc.contributor.author | Droste J. | en_US |
dc.contributor.author | Efficace F. | en_US |
dc.contributor.author | Smith A. | en_US |
dc.contributor.author | Bowen D. | en_US |
dc.contributor.author | De Witte T. | en_US |
dc.date.accessioned | 2019-09-23T10:16:37Z | - |
dc.date.available | 2019-09-23T10:16:37Z | - |
dc.date.issued | 2018-06-01 | - |
dc.identifier.issn | 8876924 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/1600 | - |
dc.description.abstract | © 2018 The Author(s). In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospecive data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Leukemia | en_US |
dc.subject | myelodysplastic syndromes | en_US |
dc.subject | health-related quality of life | en_US |
dc.title | Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: A European LeukemiaNet study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1038/s41375-018-0089-x | - |
dc.identifier.pmid | 32 | - |
dc.identifier.scopus | 2-s2.0-85044352240 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85044352240 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 1392 | en_US |
dc.relation.firstpage | 1380 | en_US |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 32 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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