The influence of structural characteristics on the in vitro drug release rate of terbinafine from topical gels

Abstract

The paper presents the results of correlated, rheological and in vitro drug release evaluation for various hydrophilic gels of terbinafine hydrochloride 1%. Linear dependence was observed between diffusion coefficient values (Higuchi model) and the concentration of cellulose derivative (1 to 4%). For the semisolid systems with concentrations of active pharmaceutical ingredient near the saturation point, selection of the nature and concentration of gel-forming excipients allows an accurate control of the delivery profile.