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https://open.uns.ac.rs/handle/123456789/14128
Nаziv: | Could phthalates exposure contribute to the development of metabolic syndrome and liver disease in humans? | Аutоri: | Nataša Milošević Maja Milanović Suđi Jan Dragana Bosić Živanović Stefan Stojanoski Bojan Vuković Nataša Milić Milica Medić Stojanoska |
Ključnе rеči: | Phthalates;Glucose metabolism;Lipid metabolism;NAFLD;Endocrine disruptor chemicals | Dаtum izdаvаnjа: | 1-јан-2019 | Čаsоpis: | Environmental Science and Pollution Research | Sažetak: | © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. In the study, 305 patients of both genders were enrolled and divided into three groups: obese (BMI > 30 kg/m2), patients who were diagnosed type 2 diabetes mellitus (T2DM), and control, normal weight healthy volunteers. At least one of ten different phthalate metabolites was determined in the urine samples of 49.84% all enrolled participants. In the obese subgroup, the sum of all urinary phthalate metabolites was positively associated with TG levels (p = 0.031) together with derived TC/HDL and TG/HDL ratios (p = 0.023 and 0.015), respectively. Urinary MEP concentration was positively correlated with the HOMA-IR in T2DM subgroup (p = 0.016) while in the control subgroup, log10MEP levels were negatively correlated with total cholesterol (p = 0.0051), and LDL serum levels (p = 0.0015), respectively. Also, in the control subgroup, positive linear correlations between urinary log10MEP levels and TyG and TYG-BMI values (p = 0.028 and p = 0.027), respectively, were determined. Urinary MEHP levels were associated with glucose serum levels (p = 0.02) in T2DM subgroup, while in the control HDL values were negatively associated with log10MEHP (p = 0.0035). Healthy volunteers exposed to phthalates had elevated AST levels in comparison to non-exposed ones (p = 0.023). In control subgroup, ALT and AST values were increased (p = 0.02 and p = 0.01, respectively) in MEP exposed while GGT levels were enhanced (p = 0.017) in MEHP exposed in comparison with non-exposed. Combined phthalates influence on glucose and lipid metabolism may increase the possibility for NAFLD and insulin resistance development among exposed individuals. | URI: | https://open.uns.ac.rs/handle/123456789/14128 | ISSN: | 9441344 | DOI: | 10.1007/s11356-019-06831-2 |
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