Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/14128
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nataša Milošević | en_US |
dc.contributor.author | Maja Milanović | en_US |
dc.contributor.author | Suđi Jan | en_US |
dc.contributor.author | Dragana Bosić Živanović | en_US |
dc.contributor.author | Stefan Stojanoski | en_US |
dc.contributor.author | Bojan Vuković | en_US |
dc.contributor.author | Nataša Milić | en_US |
dc.contributor.author | Milica Medić Stojanoska | en_US |
dc.date.accessioned | 2020-03-03T14:55:02Z | - |
dc.date.available | 2020-03-03T14:55:02Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.issn | 9441344 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/14128 | - |
dc.description.abstract | © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. In the study, 305 patients of both genders were enrolled and divided into three groups: obese (BMI > 30 kg/m2), patients who were diagnosed type 2 diabetes mellitus (T2DM), and control, normal weight healthy volunteers. At least one of ten different phthalate metabolites was determined in the urine samples of 49.84% all enrolled participants. In the obese subgroup, the sum of all urinary phthalate metabolites was positively associated with TG levels (p = 0.031) together with derived TC/HDL and TG/HDL ratios (p = 0.023 and 0.015), respectively. Urinary MEP concentration was positively correlated with the HOMA-IR in T2DM subgroup (p = 0.016) while in the control subgroup, log10MEP levels were negatively correlated with total cholesterol (p = 0.0051), and LDL serum levels (p = 0.0015), respectively. Also, in the control subgroup, positive linear correlations between urinary log10MEP levels and TyG and TYG-BMI values (p = 0.028 and p = 0.027), respectively, were determined. Urinary MEHP levels were associated with glucose serum levels (p = 0.02) in T2DM subgroup, while in the control HDL values were negatively associated with log10MEHP (p = 0.0035). Healthy volunteers exposed to phthalates had elevated AST levels in comparison to non-exposed ones (p = 0.023). In control subgroup, ALT and AST values were increased (p = 0.02 and p = 0.01, respectively) in MEP exposed while GGT levels were enhanced (p = 0.017) in MEHP exposed in comparison with non-exposed. Combined phthalates influence on glucose and lipid metabolism may increase the possibility for NAFLD and insulin resistance development among exposed individuals. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Environmental Science and Pollution Research | en_US |
dc.subject | Phthalates | en_US |
dc.subject | Glucose metabolism | en_US |
dc.subject | Lipid metabolism | en_US |
dc.subject | NAFLD | en_US |
dc.subject | Endocrine disruptor chemicals | en_US |
dc.title | Could phthalates exposure contribute to the development of metabolic syndrome and liver disease in humans? | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1007/s11356-019-06831-2 | - |
dc.identifier.scopus | 2-s2.0-85076127499 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85076127499 | - |
dc.description.version | Published | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.dept | Medicinski fakultet | - |
crisitem.author.dept | Medicinski fakultet | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.orcid | 0000-0002-5286-3858 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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