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https://open.uns.ac.rs/handle/123456789/13507
Title: | Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer | Authors: | Injac R. Perse M. Cerne M. Potocnik N. Radic N. Govedarica, Biljana Đorđević, Aleksandar Cerar A. Strukelj B. |
Issue Date: | 1-Feb-2009 | Journal: | Biomaterials | Abstract: | The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100 mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5 mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100 mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox. © 2008 Elsevier Ltd. All rights reserved. | URI: | https://open.uns.ac.rs/handle/123456789/13507 | ISSN: | 01429612 | DOI: | 10.1016/j.biomaterials.2008.10.060 |
Appears in Collections: | Naučne i umetničke publikacije |
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