Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/13507
Title: Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
Authors: Injac R.
Perse M.
Cerne M.
Potocnik N.
Radic N.
Govedarica, Biljana
Đorđević, Aleksandar 
Cerar A.
Strukelj B.
Issue Date: 1-Feb-2009
Journal: Biomaterials
Abstract: The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100 mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5 mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100 mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox. © 2008 Elsevier Ltd. All rights reserved.
URI: https://open.uns.ac.rs/handle/123456789/13507
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2008.10.060
Appears in Collections:Naučne i umetničke publikacije

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