Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/13507
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Injac R. | en_US |
dc.contributor.author | Perse M. | en_US |
dc.contributor.author | Cerne M. | en_US |
dc.contributor.author | Potocnik N. | en_US |
dc.contributor.author | Radic N. | en_US |
dc.contributor.author | Govedarica, Biljana | en_US |
dc.contributor.author | Đorđević, Aleksandar | en_US |
dc.contributor.author | Cerar A. | en_US |
dc.contributor.author | Strukelj B. | en_US |
dc.date.accessioned | 2020-03-03T14:52:37Z | - |
dc.date.available | 2020-03-03T14:52:37Z | - |
dc.date.issued | 2009-02-01 | - |
dc.identifier.issn | 01429612 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/13507 | - |
dc.description.abstract | The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100 mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5 mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100 mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox. © 2008 Elsevier Ltd. All rights reserved. | en |
dc.relation.ispartof | Biomaterials | en |
dc.title | Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1016/j.biomaterials.2008.10.060 | - |
dc.identifier.scopus | 2-s2.0-57849125020 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/57849125020 | - |
dc.description.version | Unknown | en_US |
dc.relation.lastpage | 1196 | en |
dc.relation.firstpage | 1184 | en |
dc.relation.issue | 6 | en |
dc.relation.volume | 30 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.orcid | 0000-0003-4120-7318 | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Appears in Collections: | Naučne i umetničke publikacije |
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