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https://open.uns.ac.rs/handle/123456789/12840
Title: | Hydrolysis of the peptide bond in N-acetylated L-methionylglycine catalyzed by various palladium(II) complexes: Dependence of the hydrolytic reactions on the nature of the chelate ligand in cis-[Pd(L)(H <inf>2</inf> O) <inf>2</inf> ] <sup>2+</sup> complexes | Authors: | Ašanin D. Rajković S. Molnar-Gabor D. Djuran M. |
Issue Date: | 1-Jan-2004 | Journal: | Monatshefte fur Chemie | Abstract: | Hydrolytic reactions between various palladium(II) complexes of the type cis-[Pd(L)(H 2 O) 2 ] 2+ in which L is ethylenediamine (en), 1,2-propylenediamine (1,2-pn), isobutylenediamine (ibn), 1,2-diaminocyclohexane (1,2-dach), N-methylethylenediamine (Meen), N,N,N′,N′,-tetramethylethylenediamine (Me 4 en), S-methyl L-cysteine (MeS-L-HCys), L-methionine (L-HMet), and 2,5-dithiahexane (dth) and dipeptide N-acetylated L-methionylglycine (MeCOMet-Gly) were studied by 1 H NMR spectroscopy. The reactions were carried out in the pH range 2.0-2.5 and at 50°C. In all these reactions, palladium(II) complex bound to a methionine residue effects the regioselective cleavage of the amide bond involving the carboxylic group of methionine. We found that the rate of hydrolysis and mechanism of this reaction are strongly dependent from the nature of the chelate ligand L in palladium(II) complexes of the type cis-[Pd(L)(H 2 O) 2 ] 2+ . © Springer-Verlag 2004. | URI: | https://open.uns.ac.rs/handle/123456789/12840 | ISSN: | 00269247 | DOI: | 10.1007/s00706-004-0232-4 |
Appears in Collections: | FF Publikacije/Publications |
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