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https://open.uns.ac.rs/handle/123456789/1259
Title: | Vitamin D supplementation in patients with alcoholic liver cirrhosis: A prospective study | Authors: | Željka Savić Vladimir Vračarić Nataša Milić Dijana Nićiforović Dragomir Damjanov Rinaldo Pellicano Milica Medić Stojanoska Ludovico Abenavoli |
Keywords: | Liver diseases;cholecalciferol;Metabolism;Liver cirrhosis;Vitamin D;alcohol-induced disorders;dietary supplements | Issue Date: | 1-Oct-2018 | Journal: | Minerva Medica | Abstract: | © 2018 Edizioni Minerva Medica. Background: The liver is involved in the metabolism of vitamin D. The prevalence of osteopenia in alcoholic liver disease (ALD) patients is 34-48%, and the prevalence of osteoporosis is 11-36%. Advanced liver disease is considered a risk factor for the development of osteoporosis. The aim of this study was to establish the relationship between vitamin D level and Child-Pugh score in patients with alcoholic liver cirrhosis (ALC), and to evaluate the effects of oral vitamin D supplementation. Methods: Seventy male ALC patients in the absence of active alcohol intake were enrolled and their clinical and laboratory data were recorded. A supplementation of cholecalciferol 1000 IU/day was administered. The vitamin D status was analyzed during the study, in patients stratified by Child-Pugh score. Results: The study was completed by fifty patients. At the enrollment, the mean level of vitamin D was 60.73±28.02, 50.53±39.52 and 26.71±12.81 nmol/L, respectively for Child-Pugh score class A, B and C. During vitamin D supplementation it was found in all the patients a significant increase of its levels during the first six months (P<0.05). However, in class C the improvement was consistent also after year (P<0.05). At the end of the study, two of seven patients initially in class C changed in class A, four from class C to B, and one remained in class C (P=0.012). Out of seventeen patients initially in class B, eleven changed to class A, and six remained in class B. Conclusions: In patients with ALC, higher level of vitamin D level is related with lower Child-Pugh score. The supplementation of 1000 IU/day of vitamin D in these patients was optimal for a period of at least six months. A decrease in the Child-Pugh score was also found, with a redistribution of the patients in different classes. | URI: | https://open.uns.ac.rs/handle/123456789/1259 | ISSN: | 264806 | DOI: | 10.23736/S0026-4806.18.05723-3 |
Appears in Collections: | MDF Publikacije/Publications |
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