Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/1259
DC Field | Value | Language |
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dc.contributor.author | Željka Savić | en_US |
dc.contributor.author | Vladimir Vračarić | en_US |
dc.contributor.author | Nataša Milić | en_US |
dc.contributor.author | Dijana Nićiforović | en_US |
dc.contributor.author | Dragomir Damjanov | en_US |
dc.contributor.author | Rinaldo Pellicano | en_US |
dc.contributor.author | Milica Medić Stojanoska | en_US |
dc.contributor.author | Ludovico Abenavoli | en_US |
dc.date.accessioned | 2019-09-23T10:14:32Z | - |
dc.date.available | 2019-09-23T10:14:32Z | - |
dc.date.issued | 2018-10-01 | - |
dc.identifier.issn | 264806 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/1259 | - |
dc.description.abstract | © 2018 Edizioni Minerva Medica. Background: The liver is involved in the metabolism of vitamin D. The prevalence of osteopenia in alcoholic liver disease (ALD) patients is 34-48%, and the prevalence of osteoporosis is 11-36%. Advanced liver disease is considered a risk factor for the development of osteoporosis. The aim of this study was to establish the relationship between vitamin D level and Child-Pugh score in patients with alcoholic liver cirrhosis (ALC), and to evaluate the effects of oral vitamin D supplementation. Methods: Seventy male ALC patients in the absence of active alcohol intake were enrolled and their clinical and laboratory data were recorded. A supplementation of cholecalciferol 1000 IU/day was administered. The vitamin D status was analyzed during the study, in patients stratified by Child-Pugh score. Results: The study was completed by fifty patients. At the enrollment, the mean level of vitamin D was 60.73±28.02, 50.53±39.52 and 26.71±12.81 nmol/L, respectively for Child-Pugh score class A, B and C. During vitamin D supplementation it was found in all the patients a significant increase of its levels during the first six months (P<0.05). However, in class C the improvement was consistent also after year (P<0.05). At the end of the study, two of seven patients initially in class C changed in class A, four from class C to B, and one remained in class C (P=0.012). Out of seventeen patients initially in class B, eleven changed to class A, and six remained in class B. Conclusions: In patients with ALC, higher level of vitamin D level is related with lower Child-Pugh score. The supplementation of 1000 IU/day of vitamin D in these patients was optimal for a period of at least six months. A decrease in the Child-Pugh score was also found, with a redistribution of the patients in different classes. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Minerva Medica | en_US |
dc.subject | Liver diseases | en_US |
dc.subject | cholecalciferol | en_US |
dc.subject | Metabolism | en_US |
dc.subject | Liver cirrhosis | en_US |
dc.subject | Vitamin D | en_US |
dc.subject | alcohol-induced disorders | en_US |
dc.subject | dietary supplements | en_US |
dc.title | Vitamin D supplementation in patients with alcoholic liver cirrhosis: A prospective study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.23736/S0026-4806.18.05723-3 | - |
dc.identifier.pmid | 109 | - |
dc.identifier.scopus | 2-s2.0-85055080064 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85055080064 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 357 | en_US |
dc.relation.firstpage | 352 | en_US |
dc.relation.issue | 5 | en_US |
dc.relation.volume | 109 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za radiologiju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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