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https://open.uns.ac.rs/handle/123456789/12143
Title: | Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro | Authors: | Simonovic M. Kojić, Vesna Jakimov D. Glumac M. Pejin B. |
Issue Date: | 1-Jan-2019 | Journal: | Natural Product Research | Abstract: | © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50 <30 µg/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 ± 0.96 µg/mL). At the same time, it was practically inactive (IC50 >300 µg/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH· (IC50 = 20.11 ± 1.77 µg/mL) and O2-· (IC50 = 47.23 ± 3.82 µg/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 ± 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 ± 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit. | URI: | https://open.uns.ac.rs/handle/123456789/12143 | ISSN: | 14786419 | DOI: | 10.1080/14786419.2019.1666391 |
Appears in Collections: | MDF Publikacije/Publications |
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