Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/12143
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Simonovic M. | en |
dc.contributor.author | Kojić, Vesna | en |
dc.contributor.author | Jakimov D. | en |
dc.contributor.author | Glumac M. | en |
dc.contributor.author | Pejin B. | en |
dc.date.accessioned | 2020-03-03T14:47:19Z | - |
dc.date.available | 2020-03-03T14:47:19Z | - |
dc.date.issued | 2019-01-01 | en |
dc.identifier.issn | 14786419 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/12143 | - |
dc.description.abstract | © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50 <30 µg/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 ± 0.96 µg/mL). At the same time, it was practically inactive (IC50 >300 µg/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH· (IC50 = 20.11 ± 1.77 µg/mL) and O2-· (IC50 = 47.23 ± 3.82 µg/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 ± 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 ± 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit. | en |
dc.relation.ispartof | Natural Product Research | en |
dc.title | Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.doi | 10.1080/14786419.2019.1666391 | en |
dc.identifier.scopus | 2-s2.0-85073999925 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85073999925 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
Appears in Collections: | MDF Publikacije/Publications |
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